Table 1.
Onset and exacerbation of EGPA during pregnancy: review of the literature.
| Pt | Age | Age at EGPA onset (years) | Onset or exacerbation at gestational age (weeks) | Asthma duration (years) | Symptoms | Eo (/μl or %) | MPO-ANCA | Treatment | Fetal outcome | Patient outcome | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 33 | 32 | 24 | 15 | PN, S, L | 4000 | NA | PSL | Labor induced at 37th gestation because of growth retardation | Good response | Debby et al. |
| 2 | 30 | 27 | 6 (Third) | 3 | A, S, PN, C, L | 3400 | NA | Pulse mPSL, PSL, IVCY | First: healthy infant, Second; spontaneous abortion, Third; fetal death | Died from myocardial infarction | Connolly et al. |
| 3 | 30 | 19 | 14 | 17 | A, L, S, PN, HT, PU | 560 | – | PSL | First: elective termination, Second: IUFD at 30th gestation, Third: healthy infant | Good response | Ogasawara et al. |
| 4 | 32 | 29 | 22 | 10 | PN,C, L, AR, A | 18% | NA | PSL | Healthy infant | Good response | Cormio et al. |
| 5 | 25 | 25 | 23 | 0.66 | L, PＮ, S, HT, PU | 4515 | NA | PSL, Azathioprine →IVCY | Emergency caesarean section for membrane rupture at 30th week. Twin two required early minimal ventilatory support. | Good response after IVCY | Barry et al. |
| 6 | 26 | 24 | 10 (Second) | Since childhood | 1st: none 2nd: GI,S, A, PN, Si | 1st: 9% 2nd: NA | + | 1st: PSL, IVCY, Azathioprine. 2nd: PSL, Azathioprine | First and second pregnancies: Healthy infant | Good response | Lima et al. |
| 7 | 37 | 37 | 16 | 3 | A, PN, L, Si, TA | 5200 | NA | PSL | Caesarean section at 36th week for membrane rupture. Healthy infant | Good response | Priori et al. |
| 8 | 19 | 17 | 21 | 2 | A, L, S, C, Si | 20% | NA | PSL, CPA, IVIG | Elective caesarean section at 34th weeks. Healthy infant. | Good response after IVIG | Rutberg et al. |
| 9 | 31 | NA | 5 | NA | S, GI, BA, PN, L, C | 4844 | + | PSL, IVIG | Termination of pregnancy at 20th week for trisomy 13 | Good response after IVIG | Hot et al. |
| 10 | 32 | 25 | 11 | 19 | PN, L | 2300 | + | PSL | Elective caesarean section for non-reassuring fetal status at 37 weeks. Healthy infant. | Good response | Our case |
EGPA, eosinophilic granulomatosis with polyangiitis; Pt, patient; Eo, eosinophils; MPO-ANCA, anti-neutrophil cytoplasmic antibodies against myeloperoxidase; PSL, prednisolone; mPSL, methylprednisolone; PN, peripheral nervous system; S, skin; L, Lung; A, asthma; C, cardiovascular, HT, hypertension; PU, proteinuria; AR, allergic rhinitis; Si, sinusitis; GI, gastrointestinal; TA, temporal arteritis; IUFD, intrauterine fetal death; CPA, cyclophosphamide; IVCY, intravenous cyclophosphamide; IVIG, intravenous immunoglobulin.