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Changes in the Expression of Critical Immune-Related Genes and the Activity of Immune Cell Populations Contribute to Decreased Immunogenicity in the Post-α-PD-1 HPD Tumors
(A) Seven genes involved in antigen processing were downregulated, whereas eight genes encoding immune checkpoints or modulators were upregulated in hyperprogressor tumors.
(B) The activity of eight immune cell populations were weakened and three were strengthened, as detected by GSVA method.
See also Figure S14.
