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. 2018 Oct 25;9:258–277. doi: 10.1016/j.isci.2018.10.021

Figure 8.

Figure 8

Activation of Inflammatory Pathways in the HPD Tumors after Anti-PD-1 Treatment

(A) GSVA identified the activation of four founder datasets of inflammation pathways.

(B) Differentially expressed genes in the inflammatory signature of RESPONSE_TO_CHEMICAL_STIMULUS; (C) Differentially expressed genes in the inflammatory signature of KEGG_CHEMOKINE_SIGNALING_PATHWAY; (D) Differentially expressed genes in the inflammatory signature of INFLAMMATORY_RESPONSE; (E) Differentially expressed genes in the inflammatory signature of CHEMOKINE_ACTIVITY. In each of the four pro-inflammatory datasets from (B–E), there were much more upregulated than downregulated genes. See also Figure S8.