Fig. 1.

Long-lasting changes in functional connectivity between the medical prefrontal cortex (mPFC) and amygdala (AMYG) in rats exposed a single-episode predator odor in an inescapable environment. rsfMRI measurement was conducted 7 days post exposure. The resting-state functional connectivity (RSFC) strength in the mPFC-AMYG circuit was significantly lower in predator odor rats relative to controls (p < 0.05, n = 8 for each group). In a control circuit, trauma exposure did not induce any changes in the connectivity of the visual system measured by RSFC between the left and right primary visual cortices (p = 0.82, two sample t-test). Bars are SEM. AMYG, amygdala; ACC, anterior cingulate cortex; CPU, caudate Putamen; NAc, nucleus accumbens; OFC, orbital cortex; VIS_L, left visual cortex; VIS_R, right visual cortex. Adapted from (Liang et al., 2014).