Fig. 4.

Visualization of the first canonical correlation effects in the insula. (A) FDG-PET glucose binding potential in the right insula was not associated with mTBI (B) or to PTSD symptoms (C) but was positively associated with depression severity (D). (E) An fMRI-based cluster in the right insula differentiated mTBI from no mTBI patients (F), and was weakly associated PTSD symptoms (G), but not depressive symptoms as measured by the Beck Depression Inventory II (BDI-II) (H). All ROIs were identified from the first canonical correlation brain map (see Fig. 2). Results are reported for to facilitate interpretation and are for visualization purposes only.