FIG 4.

Loop 1 of A3H in combination with either loop 7 or α-helix 6 can relocalize A3A to the nucleus through an active import mechanism. (A and C) Structural representation of A3H overlaid with A3A to highlight the orientations of loop 1, α-helix 6, and loop 7 within the RNA binding interface. (B and D) Representative images of cells expressing the indicated mCh-A3A construct. Scale bars, 5 μm. (E) Representative images of the indicated construct with either 1× or 3× mCherry. (F) Representative images of A3A chimeras with loop 1 exchanged from either A3H or A3B alone or in combination with A3H loop 7 or α-helix 6. Scale bars, 10 μm.