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Schematic showing the different roles of native and polyubiquitinated Degs1 forms in regulating prosurvival/growth and apoptotic pathways in HEK293T cells. Native Degs1 is proposed to regulate the formation of apoptotic ceramide species, while polyubiquitinated Degs1 forms are proposed to regulate the formation of prosurvival/growth ceramide species. ROS, reactive oxygen species.
