Table 3.

Effect of Mbd1^−/− (KO) on membrane input resistance (R_in) and other AP parameters in the DRG neurons^a

	Large cell			Medium cell			Small cell
	WT	MBD1 KO	t/p	WT	MBD1 KO	t/p	WT	MBD1 KO	t/p
n	18 cells, 5 mice	21 cells, 6 mice	—	19 cells, 5 mice	16 cells, 6 mice	—	22 cells, 5 mice	16 cells, 6 mice	—
Rin, mΩ	75.58 ± 22.08	31.33 ± 2.42	2.152/0.038	173.36 ± 23.20	45.68 ± 3.52	4.998/<0.001	265.99 ± 14.24	44.16 ± 4.38	−12.923/<0.001
APT, mV	−22.08 ± 2.56	−16.24 ± 1.25	−2.144/0.039	−31.33 ± 3.40	−16.12 ± 0.88	4.006/<0.001	−32.27 ± 1.82	−14.81 ± 0.93	−7.696/<0.001
APO, mV	28.22 ± 3.69	35.22 ± 2.87	−1.519/0.137	37.03 ± 4.11	36.77 ± 4.02	−0.046/0.964	35.99 ± 4.39	43.99 ± 2.79	−1.407/0.168
APA, mV	84.42 ± 3.83	94.09 ± 2.99	2.019/0.051	89.13 ± 4.00	93.28 ± 3.56	−0.762/0.451	85.31 ± 4.12	97.03 ± 2.92	2.153/0.038
AHPA, mV	−12.36 ± 1.13	−14.53 ± 1.38	−1.196/0.239	−14.01 ± 1.22	−15.73 ± 2.04	0.751/0.458	−15.17 ± 1.61	−15.08 ± 1.66	0.039/0.969

^aValues are mean ± SEM. R_in, Membrane input resistance; APA, action potential amplitude; APT, action potential threshold; APO, action potential overshoot; AHPA, afterhyperpolarization amplitude.