Fig. 1.

Physiological changes in the experimental groups. Independent of CNR1 genotype and compared to a non-stressful control manipulation, exposure to the TSST led to significant increases in (A) salivary cortisol concentrations and (B) systolic blood pressure. Whereas stress also increased (C) diastolic blood pressure, this increase was only observed in rs1049353 GG genotype carriers. Stress vs Control ^***P < 0.001 ^*P < 0.05, Stress/GG genotype vs all other groups ^###P < 0.001 ^#P < 0.01, error bars represent SEM.