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. 2018 Nov 13;2(21):3012–3024. doi: 10.1182/bloodadvances.2018020065

Figure 2.

Figure 2.

Genetic silencing of HDAC6 in euTCL1 mice. (A) Intracellular HDAC6 protein expression in CD19+ B220+ B cells from WT or euTCL1 peripheral blood (PB), as determined by flow cytometry (n = 9 per group). (B) Overall survival of indicated groups of mice (n = 5 per group), representing results of 3 independent experiments. (C) CLL burden quantified in PB or spleen by flow cytometry (n = 5 per group), representing results of at least 3 independent experiments. (D) Compilation of spleen weight data at the end of the study (n = 3 per group). (E) Representative spleens from each group indicated. (F) Spleen tyrosine kinase (SYK) messenger RNA (mRNA) expression in aged mice (n = 3 per group) normalized to 18s control gene. *P < .05, **P < .005, ***P < .0005.