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. 2018 Oct 31;2(21):2862–2878. doi: 10.1182/bloodadvances.2018020123

Figure 3.

Figure 3.

Differential gene expression in CD16+and CD16− MDDCs in response to LPS. Transcriptional profiling was performed as described in Figure 1A,E-F with matched MDDC subsets exposed to media (immature) or LPS (mature) for 24 hours. Shown are top-regulated genes in immature and mature CD16+ compared with CD16− MDDCs (A) and differentially expressed genes in CD16+ vs CD16− MDDC subsets exposed to LPS (P < .05; FC cutoff, 1.3) linked to the gene ontology terms chemotaxis (B) and cytokines (C). Heat map cells are scaled by the expression level z-scores for each probe individually. Results were generated with cells from 5 different donors identified with different color codes.