Figure 1.

High-fat diet (HFD)-induced obesity and changes in adipokine levels in a mouse model of asthma. Mice were fed standard chow or HFD for 12 weeks. (A) Representative images of mice and organs. (B) Body weight in mice on a normal diet or HFD. (C) Leptin and adiponectin levels and leptin/adiponectin ratio in the bronchoalveolar lavage fluid as determined by enzyme-linked immunosorbent assay. Results are expressed as mean ± SEM (n = 5 to 7 per group). CON, control; OVA, ovalbumin. ^ap < 0.05, ^bp < 0.01, ^cp < 0.001 vs. CON group, and ^dp < 0.05, ^ep < 0.001 vs. OVA group.