Figure 4.

Effects of anti-interleukin 17 (IL-17) antibody treatment on airway hyper-responsiveness (AHR) and allergic airway inflammation in a mouse model of obesity-related asthma. Ovalbumin (OVA) and high-fat diet (HFD)-OVA mice were treated with the anti-IL-17 antibody to deplete IL-17 and were sacrificed 24 hours after the final OVA challenge. (A) AHR and (B) inflammatory cell infiltration in the bronchoalveolar lavage fluid (BALF) were measured. (C) Paraffin-embedded lung tissue sections stained with H&E and periodic acid-Schiff (PAS) (×200). Results are expressed as mean ± SEM (n = 5 to 9 per group). CON, control. ^ap < 0.05, ^bp < 0.01, ^cp < 0.001 vs. control group, ^dp < 0.05, ^ep < 0.01, ^fp < 0.001 vs. OVA group, and ^gp < 0.05, ^hp < 0.01, ⁱp < 0.001 vs. HFD-OVA group