Effects of IL-22-FP on PCNA, CyclinB1, STAT3, and p-STAT3 activation after PHx. After euthanasia, the residual mouse liver was frozen for Western blot analysis. (a, b) PCNA expression was obviously increased in the ConA + PHx + IL-22-FP group compared with that in the other three groups at 40 h post-PHx in the ConA model. ∗∗p < 0.01 and ∗∗∗p < 0.001. (c, d) Expression of CyclinB1, PCNA, and p-STAT3 was obviously increased in the CCl4 + PHx + IL-22-FP group compared with that in the other three groups at 40 h post-PHx in the CCl4 model (all statistics were compared with the CCl4 + PHx + IL-22-FP group). ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001.