Table 1.
Factor | Porquet [15] | Varamini [16] | Yu (this paper) | |
---|---|---|---|---|
Model | SAMP8 | wildtype; APP/PS | JNPL3 | |
# of mice | 10-12 v. 10-12 | 3 v. 6; 6 v. 3 | 9 v. 8 | |
Age | 2 months | 12 months | 11 months | |
Duration | 7 months | 4 months | 3 months | |
Dose | ~0.09 mg/g, daily | ~0.17 mg/g, daily | 0.10mg/g, 5 times/wk | |
Assay | ptau v. tau blot | ptau v. tau blot | ptau sections | ptau v. tau blot |
Fraction | 10k g supernatant | 13k g supernatant | all | PHF |
Effect | Decrease | no change | decrease | no change |