Table 2.
Rat PK profiles of TIMP3 molecules. N‐TIMP3 and TIMP3v2 (K22S/F34N) were continuously infused for 6‐8 h (3 and 10 mg/kg/hr) via jugular vein in Sprague Daley rats (n = 3 per group)
| TIMP3 | Dose (mg/kg/h) | nmol/kg/h | Concentrationa (nmol/L) | Clearance (L/h/kg) | T 1/2 (h) |
|---|---|---|---|---|---|
| N‐TIMP3 | 3 | 215 | 82 ± 59 | 4.27 ± 1.95 | 2.73 ± 0.77 |
| 10 | 720 | 382 ± 20 | 1.97 ± 0.16 | 0.66 ± 0.02 | |
| TIMP3v2 | 3 | 140 | 132 ± 57 | 1.28 ± 0.21 | 0.12 ± 0.01 |
| 10 | 460 | 2552 ± 598 | 0.35 ± 0.07 | 0.68 ± 0.16 |
Blood was collected during infusion and 4 h after infusion. Plasma TIMP3 levels were quantified in ELISA. Concentration and T 1/2 data are expressed as the mean ± SEM.
Plasma TIMP3 concentrations at terminal infusion points.