Table 1: Overview of RCTs Comparing Culprit Only to Multivessel Revascularisation in Acute STEMI Patients.

RCT	Inclusion period	Culprit only (n)	Complete, index (n)	Complete, staged (n)	Lesion criteria ( % stenosis)	Type of complete revascularisation	Primary endpoint	FUP, months (mean)	Outcome
Politi et al.	2003–2007	84	65	65	≥70 % stenosis in ≥2 N-IRAs	Index complete, or staged after 2 months	MACE	30	63 % relative risk reduction of MACE after immediate complete revascularisation, 60 % after staged revascularisation
PRAMI	2008–2013	231	234	na	≥50 %	Immediate or no preventive PCI	Composite: death from cardiac cause, MI, refractory angina	23	65 % relative risk reduction in primary endpoint due to complete revascularisation, no significant difference in death
DANAMI-3 PRIMULTI	2011–2014	313	na	314	≥50 % in at least 1 N-IRA	Staged FFR guided before discharge	Composite: all-cause death, MI, ischemia-driven revascularisation	27	44 % relative risk reduction in primary endpoint due to reduction in ischaemia-driven revascularisation in complete revascularisation
CvULPRIT	2011–2013	146	97	42	≥50 % in 2 vessels, ≥70 % in 1 vessel	Immediate (recommended) or during index admission	MACE (all-cause mortality, MI, heart failure, ischemia-driven revascularisation	12	55 % relative risk reduction in primary endpoint in the complete revascularisation group
COMPARE ACUTE	2011–2015	590	295	na	≥50 % + FFR ≤0.80	Immediate FFR guided	Composite: all-cause mortality, MI, any revascularisation, cerebrovascular events	36	65 % relative risk reduction of primary endpoint in complete revascularisation (revascularisation driven)

RCT = randomized controlled trial; FUP = follow up; N-IRA = non-infarct related artery; MACE = major adverse cardiovascular event; PCI = percutaneous coronary intervention; MI = myocardial infarction; FFR = fractional flow reserve.