Table 1.
Parameters at Baseline and After 4 h for Vehicle and BMS-986231 0.7, 2, and 7 μg/kg/min
| Vehicle |
LV Function (n = 7) |
|||||||
|---|---|---|---|---|---|---|---|---|
| BMS-986231 (0.7 μg/kg/min) |
BMS-986231 (2 μg/kg/min) |
BMS-986231 (7 μg/kg/min) |
||||||
| Baseline | 4 h (%Δ From Baseline) | Baseline | 4 h (%Δ From Baseline) | Baseline | 4 h (%Δ From Baseline) | Baseline | 4 h (%Δ From Baseline) | |
| HR, beats/min | 83 ± 1 | 82 ± 3 (−2 ± 4) | 77 ± 1 | 76 ± 1 (−2 ± 1) | 87 ± 3 | 86 ± 4 (−1 ± 3) | 84 ± 2 | 84 ± 2 (−0.3 ± 3) |
| MAP, mm Hg | 76 ± 2 | 73 ± 2 (−4 ± 1) | 76 ± 2 | 72 ± 3 (−5 ± 2) | 78 ± 2 | 76 ± 2 (−1 ± 3) | 79 ± 3 | 70 ± 3∗† (−11 ± 3) |
| SAP, mm Hg | 89 ± 2 | 87 ± 2 (−2 ± 0.9) | 92 ± 2 | 89 ± 2 (−3 ± 2) | 90 ± 3 | 89 ± 2 (−1 ± 2) | 91 ± 3 | 86 ± 3 (−6 ± 3) |
| LVEDP, mm Hg | 14 ± 0.4 | 14 ± 0.6 (0 ± 3) | 13 ± 0.5 | 13 ± 0.6 (−3 ± 3) | 14 ± 0.4 | 13 ± 0.5 (−6 ± 4) | 14 ± 0.3 | 12 ± 0.8∗‡ (−14 ± 4) |
| LVEDV, ml | 85 ± 4 | 84 ± 4 (−1 ± 0.7) | 83 ± 5 | 80 ± 5∗ (−4 ± 1) | 86 ± 4 | 81 ± 4∗ (−6 ± 2) | 85 ± 4 | 78 ± 4‡ (−9 ± 2) |
| LVESV, ml | 61 ± 4 | 60 ± 4 (−1 ± 1) | 58 ± 5 | 51 ± 4∗‡ (−12 ± 0.9) | 61 ± 4 | 50 ± 2∗†‡ (−18 ± 2) | 60 ± 4 | 48 ± 3∗†‡ (−19 ± 2) |
| SV, ml | 24 ± 0.9 | 24 ± 0.8 (0.1 ± 1) | 25 ± 1 | 29 ± 2∗‡ (14 ± 3) | 25 ± 1 | 31 ± 2∗‡ (23 ± 7) | 25 ± 0.9 | 30 ± 1∗‡ (18 ± 2) |
| CO, l/min | 2.01 ± 0.06 | 1.97 ± 0.07 (−2 ± 5) | 1.94 ± 0.07 | 2.18 ± 0.13∗ (12 ± 3) | 2.20 ± 0.08 | 2.67 ± 0.16∗‡ (22 ± 8) | 2.11 ± 0.06 | 2.47 ± 0.11∗ (17 ± 5) |
| LVEF, % | 29 ± 1 | 29 ± 1 (2 ± 1) | 31 ± 2 | 36 ± 2∗‡ (18 ± 2) | 30 ± 1 | 38 ± 1∗†‡ (30 ± 6) | 30 ± 0.6 | 38 ± 0.7∗†‡ (30 ± 2) |
| LVFAS, % | 28 ± 2 | 27 ± 2 (−1 ± 2) | 27 ± 2 | 33 ± 2∗‡ (25 ± 5) | 26 ± 2 | 35 ± 2∗‡ (31 ± 3) | 26 ± 2 | 37 ± 2∗†‡ (48 ± 8) |
| Mean aortic flow, ml/s | 27 ± 2 | 27 ± 2 (−0.2 ± 2) | 27 ± 2 | 33 ± 2∗‡ (25 ± 6) | 27 ± 2 | 34 ± 3∗‡ (24 ± 4) | 27 ± 2 | 36 ± 3∗‡ (32 ± 5) |
| SVR (dynes·s·cm−5) | 3,060 ± 141 | 3,009 ± 120 (−0.5 ± 6) | 3,164 ± 170 | 2,706 ± 165∗ (−15 ± 3) | 2,847 ± 129 | 2,354 ± 189∗ (−17 ± 5) | 3,002 ± 114 | 2,298 ± 143∗‡ (−23 ± 5) |
| LV peak +dP/dt, mm Hg/s | 1,476 ± 85 | 1,595 ± 105 (10 ± 10) | 1,442 ± 102 | 1,517 ± 98 (6 ± 4) | 1,482 ± 110 | 1,560 ± 79 (7 ± 5) | 1,435 ± 75 | 1,458 ± 85 (3 ± 6) |
| Ei/Ai | 4.2 ± 0.4 | 4.1 ± 0.4 (−2 ± 2) | 4.1 ± 0.3 | 5.7 ± 0.6∗‡ (41 ± 13) | 4.1 ± 0.3 | 5.8 ± 0.5∗‡ (42 ± 4) | 3.6 ± 0.4 | 6.3 ± 0.7∗‡ (80 ± 20) |
| DT, ms | 77 ± 2 | 77 ± 2 (−0.3 ± 2) | 75 ± 2 | 86 ± 2∗‡ (14 ± 2) | 74 ± 3 | 87 ± 3∗‡ (17 ± 5) | 76 ± 2 | 89 ± 2∗‡ (16 ± 2) |
| LVEDWS, g/cm2 | 69 ± 6 | 67 ± 6 (−4 ± 4) | 65 ± 7 | 55 ± 6∗ (−14 ± 3) | 69 ± 8 | 58 ± 3∗ (−12 ± 6) | 70 ± 5 | 57 ± 4∗ (−19 ± 4) |
| MVO2, μmol/min | NT | NT | 52 ± 12 | 61 ± 13 (13 ± 5) | NT | NT | 170 ± 11 | 97 ± 7∗† (−42 ± 5) |
Values are mean ± SEM.
Δ = change; CO = cardiac output; DT = deceleration time of early mitral inflow velocity; Ei/Ai = ratio of Ei (time−velocity integral of the mitral inflow velocity waveform representing early filling) to Ai (time−velocity integral representing left atrial contraction); HR = heart rate; LV = left ventricular; LVEDP = LV end-diastolic pressure; LVEDV = LV end-diastolic volume; LVEDWS = LV end-diastolic circumferential wall stress; LVEF = LV ejection fraction; LVESV = LV end-systolic volume; LVFAS = LV fractional area shortening; LV peak +dP/dt = peak rate of change of LV pressure during isovolumic contraction; MAP = mean arterial pressure; MVO2 = myocardial oxygen consumption; NT = not tested; SAP = systolic arterial pressure; SV = stroke volume; SVR = systemic vascular resistance.
p < 0.05 vs. baseline.
p < 0.05 vs. 0.7-μg/kg/min dose infusion.
p < 0.05 vs. vehicle.