Table 3.
Parameters at Baseline and 2 h in Animals That Underwent Programmed Ventricular Stimulation (vehicle and BMS-986231 7 μg/kg/min)
| Extrastimuli-Provoked VF or SVT >30 s (n = 7) |
||||
|---|---|---|---|---|
| Vehicle |
BMS-986231 (7 μg/kg/min) |
|||
| Baseline | 2 h (%Δ from baseline) | Baseline | 2 h (%Δ from baseline) | |
| HR, beats/min | 83 ± 3 | 81 ± 2 (−2 ± 4) | 83 ± 1 | 81 ± 2 (−2 ± 4) |
| MAP, mm Hg | 80 ± 2 | 80 ± 2 (0.9 ± 2) | 78 ± 2 | 81 ± 3 (3 ± 5) |
| SAP, mm Hg | 94 ± 2 | 93 ± 2 (−0.5 ± 2) | 90 ± 1 | 92 ± 3 (2 ± 5) |
| DAP, mm Hg | 69 ± 2 | 69 ± 2 (1 ± 3) | 69 ± 2 | 70 ± 3 (3 ± 6) |
| LVEDV, ml | 82 ± 3 | 82 ± 2 (−0.1 ± 0.6) | 82 ± 2 | 81 ± 2 (−2 ± 1) |
| LVESV, ml | 57 ± 2 | 57 ± 2 (−0.1 ± 1) | 57 ± 2 | 45 ± 2∗ (−20 ± 2†) |
| SV, ml | 26 ± 1 | 26 ± 1 (−0.1 ± 3) | 26 ± 1 | 35 ± 1∗ (37 ± 4†) |
| CO, l/min | 2.12 ± 0.11 | 2.08 ± 0.14 (−1.4 ± 6.8) | 2.13 ± 0.09 | 2.85 ± 0.09∗ (35.1 ± 6.7†) |
| LVEF, % | 31 ± 1 | 31 ± 1 (−0.4 ± 3) | 31 ± 1 | 44 ± 1∗ (42 ± 5†) |
| LVFAS, % | 32 ± 1 | 33 ± 1 (3 ± 2) | 33 ± 2 | 41 ± 2∗ (27 ± 5†) |
| Threshold score | — | 9 ± 0.7 | — | 18 ± 3∗ |
| Conversion by DC shock | — | 7/7 (100%) | — | 7/7 (100%) |
Values are mean ± SEM or n/N (%), unless otherwise indicated.
DAP = diastolic arterial pressure; DC = direct current; SVT = sustained monomorphic ventricular tachycardia; VF = ventricular fibrillation; other abbreviations as in Table 1.
∗
p < 0.05 vs. baseline.
†
p < 0.05 vs. percentage change in vehicle.