Table 1.

Previously reported procedures for SPE of 5-Fu.

NO.	Solid phase type	Determination technique	Medium	Linearity	LOD	LOQ	Recovery	Ref.
1	OasisWax extraction cartridge	LC-MS/MS	human cultured cellular matrix	7.5–150 (ng/ml)	-	7.5 (ng/ml)	85%	(37)
3	Oasis HLB (copolymer of poly(di- vinylbenzene-co-N-vinylpyrrolidone)) cartridge column	LC-MS	human plasma	0.05–25 (μg/ml)	-	8.4 (ng/ml)	73.1–74.8%	(38)
4	Isolute ENV+ column	GC–MS/MS	hospital water (waste and surface water)	2-106 (ng/L)	0.48 (ng/L) for waste and 0.16 (ng/L) for surface water	1.6 (ng/L) for waste and 0.54 (ng/L) for surface water	53% for waste and 93% for surface water	(39)
5	ENV+ columns	Capillary electrophoresis	hospital waste water samples	5–500 (μg/ml)	1.7 (μg/ml)	8.6 (μg/ml)	80–96%	(40)
6	Isolute ENV+ cartridges	GC/MS-MS	hospital waste water	0.09–40 (μg/L)	12 (ng/L)	40 (ng/ml)	93–101%	(41)
7	C18 Chem Elut Cartridge	HPLC	human plasma	25–1000 (ng/ml)	-	20 (ng/ml)	35%	(42)
8	AgNPs@MCM-41-HF	capillary electrophoresis with in-column field-amplified sample injection	Human plasma	25–1000 (ng/ml)	-	25 (ng/ml)	98%	[43]