Table 4. Accuracy of different head circumference screening criteria in detecting congenital malformations, Salvador, Brazil, April 2015–July 2016 (n = 365).
| Criteria | Sensitivity | Specificity | PPV | NPV | ||||
|---|---|---|---|---|---|---|---|---|
| % | 95% CI | % | 95% CI | % | 95% CI | % | 95% CI | |
| Fenton Preterm Growth Chart | 67.7 | 59.0–75.5 | 60.6 | 52.9–67.9 | 56.6 | 48.5–64.4 | 71.1 | 63.2–78.3 |
| INTERGROWTH-21st standards | 63.4 | 54.7–71.6 | 72.4 | 65.1–78.9 | 63.9 | 55.1–72.1 | 72.0 | 64.7–78.5 |
| WHO Child Growth Standards | 75.5 | 66.2–83.3 | 54.2 | 46.3–61.9 | 51.0 | 42.9–59.0 | 77.8 | 69.2–84.9 |
| Brazilian MoH (Nov–11 Dec 2015) | 83.6 | 76.4–89.3 | 7.3 | 3.9–12.1 | 41.3 | 35.5–47.3 | 36.1 | 20.8–53.8 |
| Brazilian MoH (12 Dec 2015–12 Mar 2016) | 79.3 | 71.6–85.7 | 11.2 | 7.0–16.7 | 41.1 | 35.2–47.2 | 40.8 | 27.0–55.8 |
| Brazilian MoH (13 Mar 2016–present) | 68.6 | 60.2–76.1 | 55.3 | 47.7–62.7 | 54.5 | 46.9–62.1 | 69.2 | 61.0–76.7 |
| Pan American Health Organization recommendation | 73.6 | 65.5–80.7 | 40.2 | 33.0–47.8 | 49.0 | 42.1–56.0 | 66.1 | 56.4–74.9 |
CI: confidence interval (95%); MoH: Ministry of Health; NPV: negative predictive value; PPV: positive predictive value; WHO: World Health Organization.