Fig. 3.
Volume of distribution. a Volume of distribution (VT) for total grey matter non-lesional white matter (WM) and T2 defined white matter lesions for the reversible two-tissue compartment model (2T4k_VB). High-affinity binding (HAB) subjects in red have a 1.5 to 2-fold higher VT than medium affinity binding (MAB) subjects in blue. No difference in VT was seen between multiple sclerosis patients (MS; closed symbols) and healthy controls (HC; open symbols) for both HABs and MABs. b VT across various regions of all patients and controls. The intra-subject variation appears to be much smaller than the inter-subject variation. c The reversible two-tissue compartment model with vascular binding component (2T4k_VB_1T1k) also identified an increase in VT for HAB subjects compared with MAB subjects, but no difference in mean regional VT for patients compared to controls for either HABs or MABs