Table 3.
Risk of incident osteopenia and osteoporosis among breast cancer survivors compared with cancer-free women, stratified by characteristics at diagnosis
| Events/person-years | Age-adjusted HR (95% CI) | MV-adjusted HRa (95% CI)a | |
|---|---|---|---|
| Age at diagnosis | |||
| Cancer-free | 67/3509 | 1.00 (reference) | 1.00 (reference) |
| ≤ 50 years | 27/651 | 2.34 (1.46–3.75) | 1.98 (1.21–3.24) |
| > 50 years | 18/375 | 1.64 (0.93–2.88) | 1.34 (0.75–2.40) |
| Menopausal status at diagnosis | |||
| Cancer-free | 67/3509 | 1.00 (reference) | 1.00 (reference) |
| Premenopausal at diagnosis | 27/728 | 1.97 (1.24–3.12) | 1.76 (1.09–2.84) |
| Postmenopausal at diagnosis | 18/298 | 2.05 (1.15–3.64) | 1.58 (0.86–2.89) |
| ER statusb | |||
| Cancer-free | 67/3509 | 1.00 (reference) | 1.00 (reference) |
| ER-negative | 7/200 | 1.68 (0.76–3.72) | 1.26 (0.54–2.94) |
| ER-positive | 32/611 | 2.32 (1.52–3.55) | 2.10 (1.34–3.29) |
Abbreviations: ER Estrogen receptor, MV Multivariable
aAdjusted for age (years), menopausal status (premenopausal, postmenopausal), bilateral oophorectomy at age < 45 years (yes, no), body mass index (kg/m2), physical activity (MET-h/wk), smoking status (never, ever), alcohol intake (g/d), and hormone replacement therapy (never, ever)
bBreast cancer survivors were restricted to stages I–III