Table 4.
Risk of incident osteopenia and osteoporosis among recent breast cancer survivors compared with cancer-free women, stratified by follow-up timea
| Events/person-years | Age-adjusted HR (95% CI) | MV-adjusted HR (95% CI)b | |
|---|---|---|---|
| Overall | |||
| Cancer-free | 67/3497 | 1.00 (reference) | 1.00 (reference) |
| Survivors | 27/475 | 2.49 (1.58–3.91) | 2.17 (1.37–3.46) |
| 0–2 years | |||
| Cancer-free | 22/1126 | 1.00 (reference) | 1.00 (reference) |
| Survivors | 14/214 | 3.15 (1.61–6.17) | 2.74 (1.37–5.47) |
| 3+ years | |||
| Cancer-free | 45/2371 | 1.00 (reference) | 1.00 (reference) |
| Survivors | 13/261 | 2.07 (1.11–3.85) | 1.85 (0.98–3.51) |
Abbreviations: MV Multivariable
aBreast cancer survivors were restricted to women diagnosed within 1 year prior to enrollment
bAdjusted for age (years), menopausal status (premenopausal, postmenopausal), bilateral oophorectomy at age < 45 years (yes, no), body mass index (kg/m2), physical activity (MET-h/wk), smoking status (never, ever), alcohol intake (g/d), and hormone replacement therapy (never, ever)
p(s) for the likelihood ratio test of the interaction between breast cancer status and time was 0.42 for age- and 0.44 for MV-adjusted models