Table 3.
The genotype and allele frequencies of rs3764880 in the second sample
| Genotypes and allele frequencies | Cases, n (%) | Controls, n (%) | OR (95%CI) | P value |
|---|---|---|---|---|
| PTB and LTBI | ||||
| Males | ||||
| TLR8 rs3764880 major allele G | 84 (79.2) | 84 (88.4) | 1 | Reference |
| TLR8 rs3764880 minor allele A | 22 (20.8) | 11 (11.6) | 1.92 (0.85–4.32) | 0.12 |
| Females | ||||
| TLR8 rs3764880 GG | 65 (63.7) | 71 (67.6) | 1 | Reference |
| TLR8 rs3764880 GA | 28 (27.5) | 31 (29.5) | 1.08 (0.56–2.09) | 0.83 |
| TLR8 rs3764880 AA | 9 (8.8) | 3 (2.9) | 4.81 (1.11–20.85) | 0.04 |
| TLR8 rs3764880 major allele G | 158 (77.5) | 173 (82.4) | 1 | Reference |
| TLR8 rs3764880 minor allele A | 46 (22.5) | 37 (17.6) | 1.56 (0.93–2.62) | 0.09 |
| LTBI and HC | ||||
| Males | ||||
| TLR8 rs3764880 major allele G | 84 (88.4) | 76 (82.6) | 1 | Reference |
| TLR8 rs3764880 minor allele A | 11 (11.6) | 16 (17.4) | 0.53 (0.23–1.25) | 0.15 |
| Females | ||||
| TLR8 rs3764880 GG | 71 (67.6) | 70 (63.1) | 1 | Reference |
| TLR8 rs3764880 GA | 31 (29.5) | 36 (32.4) | 0.85 (0.47–1.52) | 0.58 |
| TLR8 rs3764880 AA | 3 (2.9) | 5 (4.5) | 0.64 (0.15–2.84) | 0.56 |
| TLR8 rs3764880 major allele G | 173 (82.4) | 176 (79.3) | 1 | Reference |
| TLR8 rs3764880 minor allele A | 37 (17.6) | 46 (20.7) | 0.83 (0.51–1.34) | 0.44 |
Abbreviations: PTB pulmonary tuberculosis, LTBI latent tuberculosis infection, HC healthy control, OR odds ratio, CI confidence interval. P value adjusted for age