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. 2018 Nov 13;6:118. doi: 10.1186/s40425-018-0435-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — The addition of αCSF-1R to GVAX therapy and αPD-1 improves survival rate in a liver metastatic pancreatic cancer murine model. a 2 × 10⁵ KPC tumor cells were inoculated via a hemispleen surgery on day 0, and mice were treated with GVAX and αPD-1 as indicated, and αCSF-1R was dosed in three different ways as shown. b Treated mice were followed for survival, and the percent survival at day 23 was calculated. No mice survived beyond day 25. GVAX + αPD-1 (n = 10), GVAX + αPD-1 + Pre-αCSF-1R (n = 9), GVAX + αPD-1 + Pre/Post-αCSF-1R (n = 9)