Figure 1. Atorvastatin (ATV)-induced and bubblehead (bbh) mutant intracerebral haemorrhage (ICH) show comparable models of brain-specific bleeding.

( A) Brain-specific bleeds were observed in both ATV and bbh models maintained on the transgenic gata1:DsRed reporter background using both brightfield (top panels) and fluorescence (bottom panels) microscopy. Bleeds formed in both forebrain and mid-hindbrain regions, as described by others ( Eisa-Beygi et al., 2013) (arrows denotes haemorrhages). Bleeds in bbh mutants are frequently associated with severe cranial oedema making blood pooling more disperse. Original magnification, x20. ( B) ATV treatment causes ICH to occur in a dose-dependent manner. ( C) Timeline of ICH development in ATV-treated and untreated embryos and ( D) bbh homozygotes.