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. 2018 Nov 8;7:1617. Originally published 2018 Oct 8. [Version 2] doi: 10.12688/f1000research.16473.2

Figure 3. ICH-induced brain injury results in a quantifiable locomotor deficit in bubblehead (bbh) zebrafish larvae.

Figure 3.

( A) Representative examples of the swimming tracks in ICH- and ICH+ larvae at 72, 96 and 120 hpf. ( B) ICH+ larvae exhibited a significant decrease in the cumulative time spent mobile during the 10 minute recording period at both 72 and 96 hpf. Significance was lost at the 120 hpf time point potentially alluding to recovery from brain injury (n=24 larvae per group; 3 independent replicates; ****p=0.00006; **p=0.003 ns p=0.08) ( C) Quantification of cumulative time spent moving in untreated and ATV-treated ICH- and ICH+ larvae at 120 hpf. ICH+ larvae exhibited a significant decrease in the cumulative time spent mobile during the 10 minute recording period. Three technical replicates (n=24 larvae per group) were used to calculate s.d from the mean (***p=0.00004, **p=0.0003).