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. 2018 Nov 8;7:1617. Originally published 2018 Oct 8. [Version 2] doi: 10.12688/f1000research.16473.2

PMC6234746.1; 2018 Oct 8
PMC6234746.2; 2018 Nov 8

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Copyright: © 2018 Crilly S et al.

This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — ( A) Representative time-lapse stills (from Supplementary Video 1) showing a ramified patrolling macrophage migrating towards an annexinV positive cell (i - vi). The macrophage acquired an amoeboid morphology (v) before phagocytosing the annexinV-positive cell (vi, vii). After phagocytosis the macrophage resumes a ramified morphology and migrates away and the annexinV-positive cell can no longer be seen (viii). Ramified macrophage (#), annexinV positive cell (arrow), amoeboid macrophage (*). ( B) Representative images of mpeg1-positive cells in the intracerebral haemorrhage (ICH)- and ICH+ larval brain exhibiting amoeboid and ramified morphologies. ( C) An increased proportion of amoeboid (phagocytic) and decreased proportion of ramified (inactive) macrophages was observed in ICH+ brains in comparison to ICH- siblings.