Table 3.
Cereulide concentrations (ng/g) in organs and tissue of pigs orally challenged with single doses of 30 and 150 μg cereulide kg-1 body weight and daily doses of 10 μg cereulide kg-1 body weight for 7 days.
| Single dose (acute trial) | Daily dose (chronic trial) | |||||
|---|---|---|---|---|---|---|
|
30 μg kg-1 |
150 μg kg-1 |
10 μg kg-1 |
||||
| Range | Average | Range | Average | Range | Average | |
| Brain | – | 0.15–1.41 | 0.73 ± 0.49 | – | ||
| Heart | – | – | – | |||
| Kidney | – | 0–0.43 | 0.21 ± 0.21 | 0.14–0.37 | 0.25 ± 0.12 | |
| Liver | – | 0.25–0.41 | 0.37 ± 0.07 | 0.06–0.24 | 0.14 ± 0.08 | |
| Spleen | – | 1.15–5.29 | 2.26 ± 1.75 | 0.10–0.21 | 0.15 ± 0.06 | |
| Lung | – | – | – | n.d. | ||
| Lymph nodes | – | 0–4.50 | 2.82 ± 1.71 | 0.01–0.14 | 0.07 ± 0.07 | |
| Large intestine | 0–0.13 | 0.07 ± 0.06 | 7.14–45.75 | 30.50 ± 14.26 | 1.16–5.05 | 3.11 ± 1.95 |
| Small intestine | – | 0.34–2.49 | 1.34 ± 0.88 | – | ||
| Stomach | – | 0.11–7.54 | 2.00 ± 3.20 | n.d. | ||
| Fat abdominal | – | 2.17–12.02 | 7.88 ± 4.17 | n.d. | ||
| Fat subcutan. | – | 0.35–1.37 | 0.74 ± 0.51 | 0–0.08 | 0.04 ± 0.04 | |
| Muscle | – | 0–0.76 | 0.39 ± 0.32 | 0–2.23 | 1.12 ± 1.12 | |
| Content large intestine | 0–0.09 | 0.07 ± 0.03 | 5.84–140.99 | 67.88 ± 50.80 | 2.04–6.78 | 4.41 ± 2.37 |
| Content small intestine | n.d. | 0–1.06 | 0.68 ± 0.53 | n.d. | ||
Animals were necropsied 48 h after dietary exposure to cereulide in the acute trials and 7 days after start of the experiment in the chronic trail. Concentration of cereulide was determined in organs and tissues by SIDA-LC-MS, using isotope labeled 13C6-cereulide as internal standard (Bauer et al., 2010).