Fig. 2.
The disruption of D2R-DAT by TAT-DATNT rescues the locomotor impairment imposed by AMPT-mediated dopamine depletion. a The AMPT treatment significantly impaired locomotor activity compared to vehicle (n = 5–6 per group). b A timewise graph illustrates the locomotor activities of dopamine-depleted animals injected with saline, TAT or TAT-DATNT (n = 6–8 per group). c TAT-DATNT (40 nmol, i.c.v.) significantly elevated the locomotor movement in the dopamine-depleted animals. All data were presented as mean ± SEM. *, p < 0.05; **, p < 0.01; ***, p < 0.001