Table 3.

Haplotypes of the tested genes concerning the analysed phenotypes in HD patients

Gene	Polymorphisms	Haplotype	Freq.	Case, Control Frequencies	Chi Square	P Value	Pcorr Valuea	OR (95% CI), p valueb	OR (95% CI), p valuec
myocardial infarction = CASES, without myocardial infarction = CONTROLS
LXRA	rs2279238_rs7120118	GT	0.693	0.646, 0.705	4.810	0.028	0.078	reference	0.761 (0.596–0.971), 0.028
		AC	0.168	0.165, 0.169	0.036	0.849	0.993	1.068 (0.777–1.468), 0.685	0.973 (0.713–1.328), 0.863
		GC	0.139	0.190, 0.126	9.791	0.002	0.005*	1.645 (1.202–2.252), 0.002	1.624 (1.194–2.208), 0.002*
	rs11039155_rs2279238_rs7120118	GGT	0.692	0.646, 0.704	4.565	0.033	0.098	reference	0.771 (0.602–0.989), 0.040
		AAC	0.160	0.157, 0.160	0.033	0.857	1.000	1.064 (0.769–1.472), 0.709	0.976 (0.710–1.342), 0.883
		GGC	0.137	0.184, 0.124	8.828	0.003	0.005*	1.598 (1.162–2.198), 0.004	1.580 (1.156–2.159), 0.004*
dyslipidaemia by K/DOQI criteria = CASES, without dyslipidaemia by K/DOQI criteria = CONTROLS
ENHO	rs72735260_rs2281997	GC	0.582	0.549, 0.619	8.786	0.003	0.008*	reference	0.756 (0.624–0.917), 0.004*
		GT	0.278	0.314, 0.238	12.299	5.0E-4	0.001*	1.483 (1.191–1.846), 0.0004	1.471 (1.189–1.819), 0.0004*
		TC	0.133	0.128, 0.138	0.434	0.5101	0.773	1.045 (0.785–1.390), 0.7645	0.921 (0.698–1.215), 0.562
atherogenic dyslipidaemia = CASES, without atherogenic dyslipidaemia = CONTROLS
ENHO	rs72735260_rs2281997	GC	0.582	0.618, 0.544	9.824	0.002	0.004*	reference	1.343 (1.109–1.627), 0.003*
		GT	0.278	0.244, 0.314	10.532	0.001	0.004*	0.687 (0.553–0.854), 0.0007	0.704 (0.570–0.869), 0.001*
		TC	0.133	0.132, 0.133	0.002	0.968	1.000	0.880 (0.661–1.172), 0.3825	0.994 (0.753–1.312), 0.966
LXRA	rs11039155_rs2279238	GG	0.827	0.803, 0.853	7.496	0.0062	0.009*	reference	0.714 (0.550–0.927), 0.011*
		AA	0.161	0.182, 0.137	6.433	0.0112	0.028*	1.401 (1.079–1.819), 0.0111	1.401 (1.079–1.819), 0.011*
	rs2279238_rs7120118	GT	0.693	0.676, 0.711	2.423	0.1196	0.249	reference	0.846 (0.689–1.039), 0.110
		AC	0.168	0.190, 0.145	6.363	0.0117	0.029*	1.386 (1.069–1.797), 0.0135	1.391 (1.077–1.796), 0.011*
		GC	0.139	0.134, 0.145	0.424	0.5151	0.795	0.978 (0.741–1.291), 0.8776	0.819 (0.699–1.207), 0.541
	rs11039155_rs2279238_rs7120118	GGT	0.692	0.676, 0.708	2.094	0.1479	0.416	reference	0.873 (0.709–1.074), 0.199
		AAC	0.160	0.180, 0.137	5.942	0.0148	0.023*	1.369 (1.049–1.785), 0.0204	1.384 (1.065–1.798), 0.015*
		GGC	0.137	0.129, 0.145	0.917	0.3382	0.750	0.935 (0.706–1.236), 0.6351	0.882 (0.669–1.162), 0.370

Significant P-values are indicated using an asterisk

^aThe p-value was calculated using the permutation test and 1000 permutations

^bThe most common haplotype was used as the reference

^cAll other haplotypes pooled together were used as the reference

Only ENHO and LXRA haplotypes yielded significant results after correction