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. 2018 Nov 9;18:176. doi: 10.1186/s12935-018-0671-3

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — IL-2 further repressed cell migration and proliferation in the presence of sorafenib. a–c An EdU assay was used to observe the proliferative cells. The number of EdU-positive cells was recorded. d–j Western blotting analysis for the proteins related to cell proliferation. IL-2 (5 ng/ml) treatment was carried out in the presence of 5 μM sorafenib. k–m A transwell assay was conducted to determine the cell migration in response to IL-2 and sorafenib co-treatment. n–r The proteins related to cell migration were analysed via western blotting. IL-2 (5 ng/ml) treatment was carried out in the presence of 5 μM sorafenib. *P < 0.05 vs. control group; ^#P < 0.05 vs. sorafenib group. Cont control