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. 2018 Nov 9;18:176. doi: 10.1186/s12935-018-0671-3

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Cell migration and proliferation were also regulated by IL-2/sorafenib co-treatment through the JNK-TAZ pathways. a–c Immunofluorescence assay for cell proliferation-related factors. IL-2/sorafenib co-treatment elevated the expression of CDK4 and cyclin D1, which was repressed by SP600125, an inhibitor of the JNK-TAZ pathways. d, e An EdU assay was performed to quantify the cell proliferation. The number of EdU-positive cells was recorded. f–h Cell migration factors such as CXCR4 and CXCR7 were measured via western blotting. *P < 0.05 vs. control group; ^@P < 0.05 vs. IL-2+ sorafenib group. Cont control