Fig. 6.

Bioreactivity of the brain, olfactory bulb, and serum of rats after 3 and 6 months of exposure to traffic-related air pollution. a 8-Isoprostane and interleukin (IL)-6 levels were determined in the cortex, cerebellum, and hippocampus in rats of the control, high-efficiency particulate air (HEPA), and particulate matter with an aerodynamic diameter of < 1 μm (PM₁). Levels of 8-isoprostane in the cortex, cerebellum, and hippocampus of rats significantly increased after 3 months of exposure. Levels of IL-6 in the hippocampus significantly increased after 3 months of exposure. b 8-Isoprostane, IL-6 and lactate dehydrogenase (LDH) levels were determined in the olfactory bulb of rats in the control, HEPA, and PM₁ groups. There were no significant differences among groups after exposure. c CCL5, CCL11, IL-4, and IL-6 were determined in the serum of rats in the control, HEPA, and PM₁ groups. Levels of CCL11 had significantly increased after 3 months of exposure to PM₁ and after 6 months of exposure to PM₁ and HEPA. IL-4 had significantly increased after 6 months of exposure to PM₁. * p < 0.05