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. 2018 Nov 7;12:782. doi: 10.3389/fnins.2018.00782

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Copyright © 2018 Long, Guo, Hu, Su, Zeng, Zeng, Tan, Ross and Pei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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14-3-3 β protein can rescue G2019S LRRK2-associated defect in mRNA expression of stress-resistance genes. (A) Expression of sod-3 in transgenic strains after heat treatment for 60 min. Human 14-3-3 β showed no effect on WT LRRK2 in mRNA expression of sod-3 (p = 0.5370). Expression of sod-3 in transgenic strains after juglone treatment for 60 min. Human 14-3-3 β showed no effect on WT LRRK2 in mRNA expression of sod-3 (p = 0.7126). (B) Expression of dod-3 in transgenic strains after heat treatment for 60 min. Human 14-3-3 β showed no effect on WT LRRK2 in mRNA expression of dod-3 (p = 0.0680). Expression of dod-3 in transgenic strains after juglone treatment for 60 min. Human 14-3-3 β showed no effect on WT LRRK2 in mRNA expression of dod-3 (p = 0.9849). (C) Expression of sod-3 in transgenic strains after heat treatment for 60 min. Human 14-3-3 β could rescue G2019S LRRK2-associated deficit in mRNA expression of sod-3 (^∗∗∗p < 0.001 versus G2019S strain). Expression of sod-3 in transgenic strains after juglone treatment for 60 min. Nematodes expressing G2019S LRRK2 showed reduced expression of sod-3 (^##p < 0.01 versus RFP strain). (D) Expression of dod-3 in transgenic strains after heat treatment for 60 min. Human 14-3-3 β could rescue G2019S LRRK2-associated deficit in mRNA expression of dod-3 (^∗∗∗p < 0.001 versus G2019S strain). Expression of dod-3 in transgenic strains after juglone treatment for 60 min. Nematodes expressing G2019S LRRK2 showed reduced expression of dod-3 (^#p < 0.05 versus G2019S strain). (E) Expression of sod-3 in transgenic strains after heat treatment for 60 min. Human 14-3-3 β showed no effect on KD LRRK2 in mRNA expression of sod-3 (p = 0.8593). Expression of sod-3 in transgenic strains after juglone treatment for 60 min. Human 14-3-3 β showed no effect on KD LRRK2 in mRNA expression of sod-3 (p = 0.7686). (F) Expression of dod-3 in transgenic strains after heat treatment for 60 min. Human 14-3-3 β showed no effect on KD LRRK2 in mRNA expression of dod-3 (p = 0.3736). Expression of dod-3 in transgenic strains after juglone treatment for 60 min. Human 14-3-3 β showed no effect on KD LRRK2 in mRNA expression of dod-3 (p = 0.4913).