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A model of LRRK2 and 14-3-3 associated DAF-16 nuclear translocation in response to stress. (A) Alignment of putative LRRK2 phosphorylation sites in FoxO family. (B) RNAi knockdown of 14-3-3 or stress (heat or juglone treatment) induced DAF-16 nuclear translocation in C. elegans expressing WT-LRRK2 or G2019S-KD LRRK2. Meanwhile, G2019S LRRK2 inhibited DAF-16 nuclear translocation, resulting in stress response deficiency which was rescued by 14-3-3.
