TABLE 2.
Multivariate Cox Regression Analysis for OS Accounting For Relevant Variables In Patients With SCC Histology
| Variable | No. | HR | P | 95% CI |
|---|---|---|---|---|
| Age (continuous variable) | 3331 | 1.029 | <.001 | 1.024-1.033 |
| Sex | ||||
| Male | 2165 | Reference | ||
| Female | 1166 | 0.924 | .140 | 0.831-1.026 |
| CDCC score | ||||
| 0 | 2707 | Reference | ||
| 1 | 477 | 1.099 | .182 | 0.957-1.261 |
| 2 | 147 | 1.637 | <.001 | 1.301-2.061 |
| Race/ethnicity | ||||
| Non-Hispanic white | 2621 | Reference | ||
| Non-Hispanic African American | 376 | 1.248 | .004 | 1.075-1.449 |
| Hispanic | 185 | 0.739 | .015 | 0.579-0.943 |
| Other/unknown | 149 | 1.144 | .271 | 0.900-1.456 |
| Y of diagnosis | ||||
| 2004-2006 | 944 | Reference | ||
| 2007-2009 | 1176 | 0.909 | .118 | 0.806-1.024 |
| 2010-2012 | 1211 | 0.903 | .133 | 0.789-1.032 |
| Tumor site | ||||
| Maxillary sinus | 1579 | Reference | ||
| Ethmoid sinus | 212 | 0.851 | .127 | 0.692-1.047 |
| Nasal cavity | 1540 | 0.620 | <.001 | 0.546-0.705 |
| Tumor classification | ||||
| T1 | 713 | Reference | ||
| T2 | 540 | 1.212 | .056 | 0.995-1.477 |
| T3 | 574 | 1.659 | <.001 | 1.358-2.027 |
| T4 | 1504 | 2.035 | <.001 | 1.700-2.436 |
| Lymph node classification | ||||
| N0 | 2736 | Reference | ||
| N1 | 238 | 1.555 | <.001 | 1.306-1.852 |
| N2/N3 | 357 | 1.600 | <.001 | 1.379-1.855 |
| Facility volume | ||||
| Low | 1054 | Reference | ||
| Mid | 1194 | 0.844 | .006 | 0.748-0.952 |
| High | 1083 | 0.888 | .064 | 0.783-1.007 |
| Surgical margin (for 1959 surgical patients) | ||||
| Negative | 1422 | Reference | ||
| Positive | 537 | 1.575 | <.001 | 1.349-1.839 |
| Therapy | ||||
| Surgery alone | 703 | Reference | ||
| RT alone | 784 | 1.294 | .001 | 1.107-1.511 |
| Chemotherapy alone | 123 | 1.834 | <.001 | 1.421-2.367 |
| Definitive chemoradiotherapy | 465 | 1.076 | .425 | 0.899-1.289 |
| Surgery plus adjuvant RT | 794 | 0.658 | <.001 | 0.553-0.784 |
| Surgery plus adjuvant chemoradiation | 333 | 0.696 | .002 | 0.555-0.874 |
| Neoadjuvant therapy | 129 | 0.656 | .007 | 0.483-0.893 |
Abbreviations: 95% CI, 95% confidence interval; CDCC, Charlson/Deyo combined comorbidity score; HR, hazard ratio; OS, overall survival; RT, radiotherapy; SCC, squamous cell carcinoma.