TABLE 3.
Logistic Regression for Negative Surgical Margins in Patients With SCC Histology Treated With Surgery and Neoadjuvant Therapy
| Variable | OR(−)margin | P | 95% CI |
|---|---|---|---|
| Tumor site | |||
| Maxillary sinus | Reference | ||
| Ethmoid sinus | 0.440 | .015 | 0.228-0.852 |
| Nasal cavity | 1.428 | .104 | 0.929-2.194 |
| Tumor classification | |||
| T1 | Reference | ||
| T2 | 0.824 | .589 | 0.408-1.663 |
| T3 | 0.254 | <.001 | 0.137-0.471 |
| T4 | 0.189 | <.001 | 0.108-0.330 |
| Lymph node classification | |||
| N0 | Reference | ||
| N1 | 0.485 | .038 | 0.245-0.959 |
| N2/N3 | 0.648 | .161 | 0.353-1.188 |
| Therapy | |||
| Surgery alone | Reference | ||
| Neoadjuvant chemotherapy plus surgery | 1.388 | .291 | 0.755-2.553 |
| Neoadjuvant RT plus surgery | 1.496 | .399 | 0.587-3.810 |
| Neoadjuvant chemoradiotherapy plus surgery | 2.641 | .045 | 1.024-6.812 |
Abbreviations: 95% CI, 95% confidence interval; OR(−)margin, odds ratio of having a negative surgical margin; RT, radiotherapy; SCC, squamous cell carcinoma.