Adult Striatal Neurons Are an Origin for iDALs
(A) iDALs come from endogenous neurons. Endogenous neurons and their derivatives were traced in Prp-CreERT;Rosa-tdT mice after Tam injections (n = 206 tdT+TH+ cells out of 259 TH+ cells from three mice). TH+ iDALs are clearly labeled by the reporter tdT. Scale bar, 20 μm.
(B) iDALs retain expression of CTIP2, a marker for striatal neurons. DA neurons in SNc were used as controls. Scale bar, 20 μm.
(C) iDALs retain expression of DARPP32, a marker for striatal neurons. DA neurons in SNc were used as controls. Scale bar, 20 μm.
See also Figures S5 and S6.