Figure 4.

Adult Striatal Neurons Are an Origin for iDALs

(A) iDALs come from endogenous neurons. Endogenous neurons and their derivatives were traced in Prp-CreER^T;Rosa-tdT mice after Tam injections (n = 206 tdT⁺TH⁺ cells out of 259 TH⁺ cells from three mice). TH⁺ iDALs are clearly labeled by the reporter tdT. Scale bar, 20 μm.

(B) iDALs retain expression of CTIP2, a marker for striatal neurons. DA neurons in SNc were used as controls. Scale bar, 20 μm.

(C) iDALs retain expression of DARPP32, a marker for striatal neurons. DA neurons in SNc were used as controls. Scale bar, 20 μm.

See also Figures S5 and S6.