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. 2018 Nov 7;8:460. doi: 10.3389/fonc.2018.00460

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Copyright © 2018 Sosa Iglesias, Theys, Groot, Barbeau, Lemmens, Yaromina, Losen, Houben, Dubois and Vooijs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pan-NOTCH/γ-secretase inhibitor BMS-906024 delays cell proliferation of H1299 cells treated with chemoradiation. Luciferase reporter assay (A) and Western Blot (B) of NCI-H1299 and NCI-H460 treated with DMSO (vehicle) or either 0.2 μM dibenzazepine (DBZ), or 0.1 or 1 μM BMS-906024. Incucyte analysis of cell confluency (%) over time of NCI-H1299 cell line for BMS-906024 1μM with/without 2 Gy radiation (C); 2.5 nM paclitaxel (D) or 0.4 μM crizotinib (E) compared to dual treatment including 1 μM BMS-906024 (left) or comparing chemoradiation with 2 Gy to triple combination including 1 μM BMS-906024 (right). A minimum of two independent experiments and 6–18 wells/condition/experiment were tested. Mean and standard error of the mean are plotted.