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. 2018 Nov 7;8:460. doi: 10.3389/fonc.2018.00460

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Copyright © 2018 Sosa Iglesias, Theys, Groot, Barbeau, Lemmens, Yaromina, Losen, Houben, Dubois and Vooijs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pan-NOTCH/γ-secretase inhibitor BMS-906024 delays H1299 multicellular spheroid specific growth in combination treatments. SSGD of multicellular NCI-H1299 spheroids were treated with 2.5 nM paclitaxel (A) or 0.4 μM crizotinib (B) and/or 1 μM BMS-906024 and/or 2 Gy radiation, is shown. Statistical significance of the comparison between single-agent chemotherapy: paclitaxel (A) or crizotinib (B), vs. chemotherapy plus BMS-906024 (left), or chemoradiation vs. chemoradiation plus BMS-906024 (right) is shown. Spheroid specific spheroid growth delay (SSGD) was calculated as T4xSV_treatment – T4xSV_control and corrected for the doubling time of the control group. A minimum of three independent biological replicates with 12 spheroids/condition/experiment were tested. Mean and standard error of the mean are plotted. p-value < 0.001 (^***) and < 0.050 (^*).