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. 2018 Nov 7;8:460. doi: 10.3389/fonc.2018.00460

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Copyright © 2018 Sosa Iglesias, Theys, Groot, Barbeau, Lemmens, Yaromina, Losen, Houben, Dubois and Vooijs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Top ranking treatment combinations in NSCLC multicellular spheroids. Comparisons in multicellular NCI-H1299 spheroids of: (A) chemotherapeutic at dose specified, and chemotherapeutic plus 0.1 or 1 μM BMS-906024; and (B) chemoradiation (with 2 or 4 Gy), and chemoradiation plus 0.1 or 1 μM BMS-906024. Red bars indicate that the addition of BMS-906024 to that treatment option conferred a statistically significant SSGD compared to the treatment without BMS-906024, and the interaction was synergistic. Green bars indicate only statistically significant SSGD. Blue bars indicate only synergistic interaction. Black bars indicate non-significant relationship.