Fig. 2.

Distribution of the subject-specific latent time shifts. The estimated latent time shifts are colored by baseline diagnostic group, a variable not included in the model. This plot suggests that the time shifts are well aligned and consistent with diagnostic criteria. The density plot also demonstrates that there is much overlap of the diagnostic criteria with respect latent time. Abbreviations: CN, cognitively normal; SMC, subjective memory concern; EMCI, early mild cognitive impairment; LMCI, late mild cognitive impairment; AD, probable Alzheimer's disease with mild-to-moderate dementia.