Figure 6.

Inflammatory Cytokines Specifically Modulate Astrocytic Secretion of Growth Factors Associated with Remyelination

Secretion of remyelinating-associated growth factors by hiPSC-derived astrocytes was analyzed following stimulation with inflammatory cytokines and compared with untreated cells (Untreated). Concentrations were measured by multiplexed bead-based immunoassay (Luminex). Conditions of stimulation are stacked in columns and growth factors analyzed in lines. For each growth factor analyzed, each of the six lines represents one study subject, starting with the three HCs (light green) then three MS patients (dark green). Each result represents the mean of two replicates of one experiment performed on one hiPSC line. Data were analyzed with a paired Friedman test (ANOVA) followed by a Dunn's multiple comparison test to assess statistical significance as compared with untreated condition (^∗p < 0.05; ^∗∗p < 0.01). NRG-1β, neuregulin-1β.