Figure 1.

Dysmorphology of Fancg^−/− Embryos Accompanied with Cellular Defect and Abnormal Hematopoietic Content in the FL and Pl

(A) smaller size and microphthalmia (blue asterisk) of Fancg^−/− embryos between E11.5 and E14.5, accompanied with a smaller size of FL (red arrowhead). Respective numbers of Fancg^−/− and WT embryos studied was n = 20 and n = 43 at E11.5, n = 186 and n = 254 at E12.5, and n = 52 and n = 53 at E14.5.

(B) Total cellularity of FL and Pl at E11.5, E12.5, and E14.5.

(C) Total number of erythroid (TER119), myeloid (GR1), and B lymphoid (B220) cells per FL and Pl at E12.5 and E14.5. Black bars, WT; white bars, Fancg^−/−.

Error bars correspond to standard deviation. ^∗∗∗p < 0.001, ^∗∗p < 0.01, ^∗p < 0.05; NS, not significant.