Table 3.
Stability and repeatability of venlafaxine (VEN) and O-desmethylvenlafaxine (ODV) in plasma
| Samples | Concentration (ng/mL) | Time (h) | Detected concentration (n=5) (ng/mL) | RSD (%) (n=5) | RSD (%) (n=15) |
| ODV | 20 | 0 | 20.36 (1.29) | 6.31 | 7.20 |
| 24 | 18.94 (0.69) | 3.65 | |||
| 48 | 20.41 (1.82) | 8.91 | |||
| 200 | 0 | 198.75 (10.76) | 5.42 | 5.05 | |
| 24 | 199.25 (13.72) | 6.88 | |||
| 48 | 197.63 (6.75) | 3.42 | |||
| 750 | 0 | 743.64 (36.43) | 4.90 | 6.41 | |
| 24 | 762.61 (58.27) | 7.64 | |||
| 48 | 769.73 (55.78) | 7.25 | |||
| VEN | 20 | 0 | 20.35 (1.13) | 5.57 | 6.25 |
| 24 | 21.27 (2.12) | 9.09 | |||
| 48 | 21.12 (0.68) | 3.24 | |||
| 200 | 0 | 207.41 (13.4) | 6.46 | 5.94 | |
| 24 | 201.98 (11.75) | 5.82 | |||
| 48 | 206.34 (13.51) | 6.55 | |||
| 750 | 0 | 770.85 (43.01) | 5.58 | 6.01 | |
| 24 | 778.72 (58.27) | 6.86 | |||
| 48 | 798.34 (52.21) | 6.60 |
RSD, relative SD.