. Author manuscript; available in PMC: 2018 Nov 14.

Published in final edited form as: Tetrahedron Lett. 2002 Jul 17;43(32):5621–5624. doi: 10.1016/S0040-4039(02)01113-9

Table 1.

Aldol reaction of ester 2 with representative aldehydes

Entry	Aldehyde	Compd^a	Yield (%)^b	syn:anti (3/4)^c
1	Me₂CHCHO	3a	89	90:10
2	Me₂CHCH₂CHO	3b	93	95:5
3	trans-PhCH=CHCHO	3c	89	96:4
4	PhCHO	3d	94	88:12
5	Me(CH₂)₆CHO	3e	96	82:18
6	Ph-C≡C-CHO	3f	86	36:64^d
7	BnOCH₂CHO	3g	74	99:1
8	BnOCH₂CH₂CHO	3h	81	99:1
9		3i	77	99:1
10		3j	82	34:66^d

Major isolated product.

Isolated yield after chromatography.

Ratios determined by ¹H MR and HPLC analysis before and after chromatography. Reaction time=1.5–2 h.

Ratio after removal of chiral auxiliary.