Table 2.
Clinicopathological characteristics according NLR, LMR, PLR, and PNI
| Characteristics | NLR | LMR | PLR | PNI | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| NLR ≤3.13 (N=448) | NLR >3.13 (N=129) | P-value | LMR ≤3.16 (N=207) | LMR >3.16 (N=370) | P-value | PLR ≤81.07 (N=90) | PLR >81.07 (N=487) | P-value | PNI ≤49.55 (N=190) | PNI >49.55 (N=387) | P-value | |
|
| ||||||||||||
| Age (years) | 0.263 | 0.658 | 0.701 | 0.501 | ||||||||
| ≤60 | 225 (50.2) | 72 (55.8) | 104 (50.2) | 197 (52.2) | 48 (53.3) | 249 (51.1) | 94 (49.5) | 203 (52.5) | ||||
| >60 | 223 (49.8) | 57 (44.2) | 103 (49.8) | 177 (47.8) | 42 (46.7) | 238 (48.9) | 96 (50.5) | 184 (47.5) | ||||
| Sex | 0.007 | <0.001 | 0.011 | 0.241 | ||||||||
| Female | 142 (31.7) | 25 (19.4) | 39 (18.8) | 128 (34.6) | 16 (17.8) | 151 (31.0) | 61 (32.1) | 106 (27.4) | ||||
| Male | 306 (68.3) | 104 (80.6) | 168 (81.2) | 242 (65.4) | 74 (82.2) | 336 (69.0) | 129 (67.9) | 281 (72.6) | ||||
| Smoking | 0.096 | 0.098 | 0.018 | 0.405 | ||||||||
| Yes | 255 (56.9) | 84 (65.1) | 131 (63.3) | 208 (56.2) | 63 (70.0) | 276 (56.7) | 107 (56.3) | 232 (59.9) | ||||
| No | 193 (43.1) | 45 (34.9) | 76 (36.7) | 162 (43.8) | 27 (30.0) | 211 (43.3) | 83 (43.7) | 155 (40.1) | ||||
| Cell types | 0.357 | 0.050 | 0.284 | 0.538 | ||||||||
| Adenocarcinoma | 260 (58.0) | 71 (55.0) | 110 (53.1) | 221 (59.7) | 47 (52.2) | 284 (58.3) | 108 (56.8) | 223 (57.6) | ||||
| Squamous | 144 (32.1) | 49 (38.0) | 82 (39.6) | 111 (30) | 31 (34.4) | 162 (33.3) | 61 (32.1) | 132 (34.1) | ||||
| Others | 44 (9.8) | 9 (7.0) | 15 (7.2) | 38 (10.3) | 12 (13.3) | 41 (8.4) | 21 (11.1) | 32 (8.3) | ||||
| Tumor differentiation | 0.350 | 0.006 | 0.837 | 0.555 | ||||||||
| Well or moderately | 274 (61.2) | 73 (56.6) | 109 (52.7) | 238 (64.3) | 55 (61.1) | 292 (60.0) | 111 (58.4) | 236 (61.0) | ||||
| Poorly or undifferentiated | 174 (38.8) | 56 (43.4) | 98 (47.3) | 132 (35.7) | 35 (38.9) | 195 (40.0) | 79 (41.6) | 151 (39.0) | ||||
| Visceral pleura invasion | <0.001 | 0.195 | 0.358 | 0.843 | ||||||||
| Yes | 290 (64.7) | 61 (47.3) | 119 (57.5) | 233 (63) | 51 (56.7) | 301 (61.8) | 117 (61.6) | 235 (60.7) | ||||
| No | 158 (35.3) | 68 (52.7) | 88 (42.5) | 137 (37) | 39 (43.3) | 186 (38.2) | 73 (38.4) | 152 (39.3) | ||||
| Bronchial invasion | 0.765 | 0.928 | 0.131 | 0.067 | ||||||||
| Yes | 117 (26.1) | 32 (24.8) | 53 (25.6) | 96 (25.9) | 29 (32.2) | 120 (24.6) | 40 (21.1) | 109 (28.2) | ||||
| No | 331 (73.9) | 97 (75.2) | 154 (74.4) | 274 (74.1) | 61 (67.8) | 367 (75.4) | 150 (78.9) | 278 (71.8) | ||||
| Postoperative chemotherapy | 0.104 | 0.114 | 0.678 | 0.639 | ||||||||
| Yes | 79 (17.6) | 15 (11.6) | 27 (13.0) | 67 (18.1) | 16 (17.8) | 78 (16.0) | 29 (15.3) | 65 (16.8) | ||||
| No | 369 (82.4) | 114 (88.4) | 180 (87.0) | 303 (81.9) | 74 (82.2) | 409 (84.0) | 161 (84.7) | 322 (83.2) | ||||
| Resected lymph node numbers | 0.689 | 0.796 | 0.072 | 0.725 | ||||||||
| <12 | 196 (43.8) | 59 (45.7) | 90 (43.5) | 165 (44.6) | 32 (35.6) | 223 (45.8) | 82 (43.2) | 173 (44.7) | ||||
| ≥12 | 252 (56.2) | 70 (54.3) | 117 (56.5) | 205 (55.4) | 58 (64.4) | 264 (54.2) | 108 (56.8) | 214 (55.3) | ||||
| Resected lymph node stations | 0.460 | 0.320 | 0.362 | 0.844 | ||||||||
| <6 | 324 (72.3) | 89 (69.0) | 143 (69.1) | 270 (73.0) | 68 (75.6) | 345 (70.8) | 137 (72.1) | 276 (71.3) | ||||
| ≥6 | 124 (27.7) | 40 (31.0) | 64 (30.9) | 100 (27.0) | 22 (24.4) | 142 (29.2) | 53 (27.9) | 111 (28.7) | ||||
Note: P-value, the correlation between clinicopathological characteristic parameters and NLR, LMR, PLR, PNI, was assessed by the chi-squared test or Fisher’s exact test.
Abbreviations: LMR, lymphocyte-to-monocyte ratio; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; PNI, prognostic nutritional index.